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Asiaticosides in Gotu Kola help to improve Type 1 collagen synthesis in skin, Type 1 collagen is the principle component of skin dermis and reduction in levels of Type 1 collagen are often associated with wrinkles, fine lines, skin sagging and discoloration

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These microbial changes correlate with higher lipopolysaccharide (LPS) and lower superoxide dismutase-1 levels (59, 60), which can lead to microbial translocation, systemic inflammation, and increased permeability of both the intestinal and blood-brain barriers (BBB), creating a vicious cycle (6165)

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